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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Carvacrol, Sorafenib
Phytochemical Name Carvacrol (PubChem CID: 10364 )
Anticancer drug Name Sorafenib (PubChem CID: 216239 )
Structure of
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2D MOL 3D MOL
Structure of
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Sorafenib
Adverse Reactions Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug.
Recommendations Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium;
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 429
Ref_1
Pair Name Carvacrol, Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Inhibition-->Epithelial-mesenchymal transition
Gene Regulation Down-regulation Expression ABCG2 hsa9429
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression CCND1 hsa595
Up-regulation Expression GSS hsa2937
Down-regulation Expression HIF1A hsa3091
Up-regulation Expression IL6 hsa3569
Down-regulation Expression LDHA hsa3939
Down-regulation Expression NOTCH1 hsa4851
Down-regulation Expression SALL4 hsa57167
Down-regulation Expression TGFB1 hsa7040
Up-regulation Expression TNF hsa7124
Down-regulation Expression TRPM7 hsa54822
Down-regulation Expression VEGFA hsa7422
Down-regulation Expression VIM hsa7431
In Vivo Model A preliminary study was conducted using 200 mg/kg of TAA dissolved in 0.2 mL of normal saline and given intraperitoneal (i.p.) twice a week for 16 weeks to induce HCC.
Result CARV/Sora is a promising combination for tumor suppression and overcoming Sora resistance and cardiotoxicity in HCC by modulating TRPM7. To our best knowledge, this study represents the first study to investigate the efficiency of CARV/ Sora on the HCC rat model. Moreover, no previous studies have reported the effect of inhibiting TRPM7 on HCC.
03. Reference
No. Title Href
1 Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7. Life Sci. 2023 Jul 1;324:121735. doi: 10.1016/j.lfs.2023.121735. Click
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